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{{Teaser-DT|Abstact der zweiten Stoffwechsel-Studie <br> von [[Lohninger, A.|Professer Lohninger]]}}

[[Bild:800px-Steinschaler zünftiges und vernünftiges1.jpg|Steinschaler Zünftiges & Vernünftiges|250px|right]]

In Kooperation mit der '''Meduni Wien''' wurden '''zwei Stoffwechselstudien''' im Dirndltal mit Beteiligung der Bevölkerung und der ansässigen Ärzte durchgeführt.

Hier das Abstract dieser zweiten Stoffwechsel-Studie.

==Auswirkungen Carnitin==

A combination of (n-3) Polyunsaturated Fatty Acids, Polyphenols and L-Carnitine reduces the Plasma Lipid Levels and increases the expression of peroxisome proliferator-activated receptor alpha and enzymes involved in Fatty Acid oxidation in human peripheral blood mononuclear cells1-2

==Autoren ==
Lohninger A3, Radler U3, Lienbacher G4, Krepp R4, Zeller E4, Brachinger M4,<br>
Eller- Berndl D4, Fischer A4, Lechner S3, Anzur C6, Laschan C5 and Anderwald C7

==Abstract==
Hyperlipidemia and obesity are associated with the metabolic syndrome and an increased risk in the development of diabetes mellitus and cardiovascular disease. Lipid-lowering drugs are widely used to reduce this risk. Alternatively nutritionally supplements e.g. L-carnitine and (n-3)-polyunsaturated fatty acids (PUFAs) exert lipid-lowering effects, not at least, by increasing mitochondrial fatty acid oxidation.
The aim of the present, prospective, placebo-controlled, double-blind study in hyperlipidemic subjects was to assess the effect of low-fat yoghurt consumption enriched with a combination of PUFAs, polyphenols and L-carnitine (PPC) on plasma lipids and enzyme expression involved in regulation of FA-oxidation in peripheral blood mononuclear cells (PBMCs).

Twenty-two moderately hyperlipidemic obese humans consuming PPC twice daily for 12 weeks, were compared with twenty matching participants ingesting low-fat yoghurt enriched with vitamins C and E.

PPC consumption led to significantly reduced (P<0.05) plasma free fatty acid (FFA -29%) and triglyceride (TG -24%) concentrations. In subjects older than 55 years, FFA levels decreased by 37% (P<0.01), whereas the TG lowering effect depends rather on TG concentration at baseline. PPC administration resulted in a moderately decreased portion of saturated FA and a moderately increased percentage of monounsaturated FA on plasma FFA.

Moreover PPC application increased the PPARα relative mRNA abundances 2.6 fold (P<0.05) in PBMCs, whereas the expression of SREBP1c was down-regulated by a factor 0.8. In addition the relative mRNA abundances of PPARα target genes CPT1A, CPT1B, CRAT and OCTN2 were enhanced by a factor of (2.1, 1.8, 2.1, and 2.7, respectively each P<0.05). In controls, plasma lipid levels and PBMC gene-expression did not change after 12 weeks.

==Conclusion==
In conclusion the supplementation of PPC had marked lipid lowering effects and the results provide convincing evidence, that PBMC gene expression profiles reflect nutrition-related metabolic changes.

[[Kategorie: English]]
[[Kategorie: Gesundheit]]
[[Kategorie: Lohninger]]

Abstract 2. Studie - Versionsgeschichte

Micscr: 1 Version importiert

quelle>Weiss am 16. Februar 2014 um 11:32 Uhr